Multi-arm polyethylene glycol blocked macroporous silicon peptide nano controlled release system as well as preparation and application thereof

The invention discloses a multi-arm polyethylene glycol blocked macroporous silicon peptide nano controlled release system as well as preparation and application thereof, and relates to the field of nano biological medicines. Macroporous silicon dioxide nanoparticles are firstly subjected to cis-aconitic anhydride functionalization, peptide anticancer drugs are simply and physically embedded, then the macroporous silicon dioxide nanoparticles and multi-arm polyethylene glycol with multiple amino groups form a drug delivery carrier in an electrostatic adsorption mode, and the macroporous silicon peptide nano controlled release system blocked by the multi-arm polyethylene glycol is formed. The defects that protein peptide drugs are easily degraded and inactivated in vivo, cannot penetrate through cell membranes and are low in oral bioavailability are overcome; the in-vivo biological stability is improved, the cell membrane permeability is enhanced, and the medication compliance of a patient is improved; the sel