Method for rapidly killing tolerant bacteria by matching n-butyl alcohol with aminoglycoside antibiotics under low ion shock condition

The invention discloses a method for rapidly killing tolerant bacteria by matching n-butyl alcohol with aminoglycoside antibiotics under a low ion shock condition; the method comprises the following steps: preparing the aminoglycoside antibiotics by using a n-butyl alcohol solution to obtain an antibiotic working solution, and then adding bacteria to be killed into the antibiotic working solution to obtain a mixture of the bacteria and the antibiotics. The method disclosed by the invention can greatly improve the sterilization efficiency of the aminoglycoside antibiotics, effectively reduce the risk that pathogenic bacteria generate drug resistance, and reduce the dosage and administration time and reduce the side effects on the premise of achieving the same treatment effect. 本发明公开了正丁醇在低离子休克条件下配合氨基糖苷类抗生素快速杀灭耐受菌的方法，该方法是用正丁醇溶液配制氨基糖苷类抗生素得到抗生素工作液，然后将带灭细菌加入上述抗生素工作液中，得到细菌与抗生素的混合物。本发明方法可以大幅度提高氨基糖苷抗生素的杀菌效率，有效降低病原菌产生耐药的风险，同时在达到同样治疗效果的前提下，减少用药量和给药时间，降低其副作用。