Preparation method of hydroxychloroquine

The invention relates to the field of medicinal chemistry, in particular to a preparation method of hydroxychloroquine. According to the method, the nucleophilic reaction is promoted by adding the organic amine, the reaction time is shortened, the reaction conversion rate is increased, the impurity content is reduced, the product quality is improved, other organic solvents and catalysts are not used, the high-pressure reaction condition is avoided, and the method is mild in reaction condition, simple in post-treatment, high in process controllability and suitable for industrial production. The preparation method of hydroxychloroquine comprises the following step: reacting 4, 7-dichloroquinoline and 2-[(4-amino amyl) (ethyl) amino] ethanol in triethanolamine to prepare hydroxychloroquine. 本发明涉及药物化学领域，具体涉及一种羟氯喹的制备方法。该方法通过加入有机胺促进亲核反应进行，缩短反应时间，提高反应转化率，降低杂质含量，提高产品质量，该方法避免使用其他有机溶剂和催化剂，避免高压的反应条件，该方法反应条件温和，后处理简单，工艺可控性强，适用于工业化生产。一种羟氯喹的制备方法，包括以下步骤：4，7-二氯喹啉和2-[(4-氨基戊基)(乙基)氨基]乙醇在三乙醇胺中进行反应制备羟氯喹。