Metal ion delivery carrier as well as preparation method and application thereof

The invention relates to a metal ion delivery carrier as well as a preparation method and application thereof. The metal ion delivery carrier comprises ferritin and a histidine tag fused at the carboxyl terminal of the ferritin. The metal ion delivery carrier comprises ferritin with the C end fused with a histidine tag, the ferritin is of a shell-shaped structure, the C end of an inner cavity is fused with the histidine tag, the ferritin can be combined with metal ions and load the metal ions, a shell can be specifically combined with tumor cells and receptors on tumor tissues, and after combination, the ferritin can be endocytosed into the tumor cells, so the metal ions are delivered into the tumor cells. 本发明涉及一种金属离子递送载体及其制备方法和应用。所述金属离子递送载体包括铁蛋白和融合在所述铁蛋白羧基端的组氨酸标签。所述金属离子递送载体包括C端融合组氨酸标签的铁蛋白，铁蛋白具有壳状结构，内腔的C端融合有组氨酸标签，能够与金属离子结合，负载金属离子，外壳能够特异结合肿瘤细胞和肿瘤组织上的受体，且结合后，能够被内吞进入肿瘤细胞，从而将金属离子递送至肿瘤细胞内。