3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure with biological activity as well as synthesis method and application of 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure
The invention discloses a 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure with biological activity as well as a synthesis method and application of the 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure. The invention provides a struct...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure with biological activity as well as a synthesis method and application of the 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene structure. The invention provides a structure of a 3, 4-position fused hetero seven-membered heterocyclic oxoindole alkene bioactive framework. The invention provides a synthesis method of the structure, which comprises the steps of reacting propargyl alcohol containing an isatin framework with a nucleophilic reagent under certain conditions to prepare the 3, 4-position fused hetero seven-membered nitrogen heterocyclic oxoindole alkene compound. The invention provides a pharmaceutical composition. The invention also provides an application of the 3, 4-position fused hetero seven-membered nitrogen heterocyclic oxoindole alkene bioactive framework in preparation of medicines for treating cancers and the like. According to the method for efficiently synthesiz |
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