Gastric cancer spleen-deficiency syndrome salivary protein marker as well as detection method and application thereof

The present invention discloses a gastric cancer spleen-deficiency syndrome saliva protein marker and the detection method and application thereof, an itraq technology is used for detecting and comparing gastric cancer spleen-deficiency syndrome, non-spleen-deficiency syndrome and normal saliva prot...

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Bibliographische Detailangaben
Hauptverfasser: LIU ZHANYAN, SUN KEHUAN, WU ZHENGZHI, CAO MEIQUN, HUANG FEIJUAN, YAO YONGCHAO, CAI YUANZHE, LIU JIEREN, DING FENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention discloses a gastric cancer spleen-deficiency syndrome saliva protein marker and the detection method and application thereof, an itraq technology is used for detecting and comparing gastric cancer spleen-deficiency syndrome, non-spleen-deficiency syndrome and normal saliva proteomes, and a proteome with significant difference of gastric cancer spleen-deficiency syndrome characteristics is found; and the biological process, the cell component and the molecular function of the differential proteome are are further enriched and classified, and the protein which executes the important molecular function and participates in the important biological process as the gastric cancer spleen-deficiency syndrome biomarker by ELISA (Enzyme-Linked Immunosorbent Assay) are verified. According to the invention, rich proteins are detected from saliva, and the saliva protein marker of the stomach cancer spleen-deficiency syndrome is screened, so that non-invasive diagnosis of the stomach cancer spleen-defi