Preparation method of cornuside bulk drug

The invention provides a preparation method of a cornuside bulk drug. The preparation method comprises the following steps: crushing dogwood fruits to obtain dogwood fruit powder, adding an extraction solvent into the dogwood fruit powder for reflux extraction to obtain an extracting solution, performing filtering, and performing vacuum concentration to obtain a concentrated solution; extracting the concentrated solution by using an organic solvent, and performing vacuum concentration to obtain an extracted water concentrated solution; sequentially carrying out macroporous adsorption resin column chromatography and polyamide resin column chromatography on the extracted water concentrated solution, then carrying out gradient elution by utilizing an elution solvent, carrying out silica gel thin-layer chromatography or high performance liquid chromatography(HPLC) inspection, collecting and combining an eluent containing cornuside, and carrying out vacuum concentration to obtain a cornuside concentrated solution;