Benzimidazole or azabenzimidazole-6-carboxylic acid compound and application thereof

The invention discloses a benzimidazole or azabenzimidazole-6-carboxylic acid compound and an application of the benzimidazole or azabenzimidazole-6-carboxylic acid compound. The benzimidazole or azabenzimidazole-6-carboxylic acid compound has a structure as shown in a formula (I). The benzimidazole...

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Hauptverfasser: QING YUANHUI, DENG XINLAN, CAI XIONG, FAN FUSHUN, LIN MINGSHENG, WENG YUNWO, HE QIJIE, FENG QIAO, LIU BIN, LIU YITING, TAN HUICHEN, QIAN CHANGGENG, WU SHAOBIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a benzimidazole or azabenzimidazole-6-carboxylic acid compound and an application of the benzimidazole or azabenzimidazole-6-carboxylic acid compound. The benzimidazole or azabenzimidazole-6-carboxylic acid compound has a structure as shown in a formula (I). The benzimidazole or azabenzimidazole-6-carboxylic acid compound can effectively activate a GLP-1R downstream signal channel and improve cAMP expression, so that the effects of promoting insulin secretion and treating diabetes mellitus and complications of diabetes mellitus are achieved, and the benzimidazole or azabenzimidazole-6-carboxylic acid compound has high application value. 本发明公开了一种苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用,所述苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物具有式(I)所示结构。该苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物可以有效激活GLP-1R下游信号通路,提高cAMP的表达,从而达到促进胰岛素分泌,治疗糖尿病及其并发症的作用,有较大的应用价值。