METHODS AND COMPOSITIONS FOR TREATING MOTOR NEURON DISEASES

Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside, pterostilbene and a phosphodiesterase (PDE) inhibitor, includi...

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Hauptverfasser:	ESTRELA ARIGUEL JOSE MARIA, SALVADOR RICARDO, DELLINGER RYAN W, OBRADOR PLA MARIA ELENA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside, pterostilbene and a phosphodiesterase (PDE) inhibitor, including a PDE4 inhibitor such as ibudilast, and also including a thiol/cysteine donor, such as acetylcysteine. 本文提供了涉及通过向受试者施用(例如，向受试者口服施用)包含烟酰胺核苷、紫檀芪和磷酸二酯酶(PDE)抑制剂(包括PDE4抑制剂，例如异丁司特)的组合物来治疗受试者的运动神经元疾病(例如ALS)的方法和组合物，该组合物还包括硫醇/半胱氨酸供体，例如乙酰半胱氨酸。