Application of Idarubicin HCl compound in preparation of medicine for treating AIDS

The invention relates to an application of an Idarubicin HCl compound in preparation of a medicine for treating AIDS. The Idarubicin HCl compound is used for preparing the medicine for treating AIDS and is applied to treatment of AIDS. The Idarubicin HCl compound can significantly increase the effic...

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Hauptverfasser: YANG GENG, KONG QINGMIN, LIU XINGZHU, LI PING, YANG YADONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an application of an Idarubicin HCl compound in preparation of a medicine for treating AIDS. The Idarubicin HCl compound is used for preparing the medicine for treating AIDS and is applied to treatment of AIDS. The Idarubicin HCl compound can significantly increase the efficiency of programmed ribosome displacement of mRNA of HIV-1 during translation of Gag-Pol fusion protein, so that the translation efficiency of Pol protein is greatly increased, serious imbalance of the ratio of Gal to Pol is caused, then the efficiency of HIV-1 virus packaging is significantly reduced, the virus cannot be packaged into a complete particle in a cell, the yield of the virus is finally sharply reduced, and a good anti-HIV effect is achieved. 本发明涉及一种Idarubicin HCl化合物作为制备治疗艾滋病药物的应用,将Idarubicin HCl化合物作为制备治疗艾滋病药物,并应用在治疗艾滋病中。Idarubicin HCl化合物能够显著增加HIV-1的mRNA在翻译Gag-Pol融合蛋白时程序性核糖体移位的效率,使Pol蛋白的翻译效率大幅度增加,导致Gal和Pol两者比率的严重失调,进而显著降低了HIV-1病毒包装的效率,致使病毒无法在细胞内包装成一个完整的颗粒,最终导致病毒的产量急剧降低,具有良好的抗HIV效果。