Rosemary essential oil nasal in-situ gel as well as preparation method and application thereof

The invention discloses rosemary essential oil nasal in-situ gel as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. The rosemary essential oil nasal in-situ gel is prepared from the following components in percentage by mass: 2 to 5 percent of rosemary essential oil clathrate compound, 18.5 to 19.5 percent of poloxamer 407, 5.5 to 6.5 percent of poloxamer 188, 4.5 to 5.5 percent of glycerol, 0.01 to 0.02 percent of methylparaben and the balance of phosphate buffer solution. The rosemary essential oil nasal in-situ gel prepared by the invention is soft and has no irritation and no adverse reaction. 本发明公开了一种迷迭香精油鼻用原位凝胶及其制备方法和应用，属于中药制药技术领域。迷迭香精油鼻用原位凝胶由以下质量百分比的组分组成：2％～5％迷迭香精油包合物、18.5％～19.5％泊洛沙姆407、5.5％～6.5％泊洛沙姆188、4.5％～5.5％甘油、0.01％～0.02％羟苯甲酯、余量为磷酸盐缓冲液。本发明制备的迷迭香精油鼻用原位凝胶柔和无刺激性，无不良反应。