Preparation method of small molecular tyrosine kinase inhibitor

The invention provides a preparation method of a small molecular tyrosine kinase inhibitor. Specifically, a compound II serving as a raw material and a compound I are subjected to a condensation reaction, then ester is reduced into aldehyde by using a reducing agent, the aldehyde and a compound V pr...

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Bibliographische Detailangaben
Hauptverfasser: LI YONGGANG, HUANG XIAOLI, LI HANPU
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention provides a preparation method of a small molecular tyrosine kinase inhibitor. Specifically, a compound II serving as a raw material and a compound I are subjected to a condensation reaction, then ester is reduced into aldehyde by using a reducing agent, the aldehyde and a compound V product are subjected to a condensation reaction, hydroxyl is removed, and pecedatinib is obtained. The preparation method disclosed by the invention has the advantages of easily available raw materials, mild reaction, environmental friendliness and certain safety, and is suitable for industrial production. 发明提供了一种小分子酪氨酸激酶抑制剂的制备方法。具体地,以化合物Ⅱ为原料与化合物Ⅰ进行缩合反应,后使用还原剂使酯还原成醛,与化合物Ⅴ产物与缩合反应后脱去羟基得培西达替尼。本发明的制备方法原料易得、反应温和、环境友好、适合工业化生产,具有一定的安全性。