Construction method of SARS-CoV-2 gastrointestinal inflammation animal model

The invention belongs to the technical field of animal model construction, and discloses a construction method of an animal model of gastrointestinal inflammation caused by SARS-CoV-2, which comprises the following steps that: before virus infection is simulated, acid enema treatment on gastrointestinal tract epithelium is performed at first; added acetic acid can cause slight injury; after the acid enema treatment is performed, the SARS-CoV-2Spike Protein is injected into the intraperitoneal cavity, so that the reappearance of the viral gastrointestinal symptoms of a mouse can be simulated; the animal model obtained by the method is consistent with clinical symptoms of a patient related to COVID-19 reported in the prior art, so that the animal model constructed by the method disclosed by the invention can copy gastrointestinal manifestations of the clinical COVID-19 patient. 本发明属于动物模型构建技术领域，公开了SARS-CoV-2引起的胃肠炎症动物模型的构建方法，是在模拟病毒感染之前，先对胃肠道上皮进行酸灌肠处理，添加的乙酸能够造成一个轻微的损伤，在进行酸灌肠处理后，再腹腔注射SARS-CoV-2Spike Protein更有利于模拟小鼠