Application of Nck1 protein as marker in diagnosis of spinal cord injury

The invention discloses application of Nck1 protein as a marker in diagnosis of spinal cord injury, and belongs to the technical field of medicine. Research finds that Nck1 protein is selectively expressed on spinal cord neuron cytoplasm and cell membrane, and spinal cord injury can lead to significant change of the protein expression level; meanwhile, the Nck1 protein is also found to be capable of regulating the proliferation of neurons and the growth and development of protuberances so as to promote the regeneration and repair of neurons. Therefore, the Nck1 protein can be used as a marker for diagnosing spinal cord injury. The invention provides a certain theoretical support for clinical treatment of spinal cord injury. 本发明公开了Nck1蛋白作为标志物在诊断脊髓损伤中的应用，属于医学技术领域。本发明通过研究发现Nck1蛋白选择性表达在脊髓神经元胞浆和胞膜上，脊髓损伤可以导致该蛋白表达水平显著性变化；同时还发现Nck1蛋白可以调节神经元增殖和突起的生长发育，进而促进神经元的再生和修复。因此，Nck1蛋白可以作为标志物用于诊断脊髓损伤。本发明为临床脊髓损伤治疗提供了一定的理论支持。