Anti-platelet aggregation polypeptide and application thereof

The invention discloses a polypeptide 15012 for resisting platelet aggregation, and belongs to the technical field of medical biology. The polypeptide disclosed by the invention is composed of 10 amino acids, has a sequence of the polypeptide as shown in SEQ ID NO: 1, has a molecular weight of 1033.05, and has a sequence of Asp-Thr-Pro-Thr-Ile-Ser-Pro-Ser-Asp-Thr. The polypeptide is not limited to inhibition of thrombin-induced platelet aggregation, can be used for exploring the influence of the polypeptide and other platelet activators (collagen, arachidonic acid, ADP, epinephrine, ristomycin and the like) on the action and related functions of platelets, and can also be used for monitoring existing antiplatelet treatment. 本发明公开一种抗血小板聚集的多肽15012，属于医药生物技术领域。本发明的多肽为由10个氨基酸组成，具有SEQ ID NO:1的多肽的序列，分子量为1033.05，序列Asp-Thr-Pro-Thr-Ile-Ser-Pro-Ser-Asp-Thr。该多肽不限定于抑制凝血酶诱导的血小板聚集，可用于探索其与其它血小板激活剂(胶原、花生四烯酸、ADP、肾上腺素、瑞斯托霉素等)对血小板的作用及相关功能的影响，还可以用于监测现有的抗血小板治疗。