Preparation method of heterogeneously catalyzed 2-trifluoromethyl substituted benzimidazole compound
The invention discloses a preparation method of a heterogeneously catalyzed 2-trifluoromethyl substituted benzimidazole compound, which comprises the following steps: adding copper-doped carbon nitride, potassium carbonate, trifluoroethylimido acyl chloride and amine into an organic solvent, reactin...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a preparation method of a heterogeneously catalyzed 2-trifluoromethyl substituted benzimidazole compound, which comprises the following steps: adding copper-doped carbon nitride, potassium carbonate, trifluoroethylimido acyl chloride and amine into an organic solvent, reacting at 70-90 DEG C for 18-30 hours, and after the reaction is completed, filtering, washing and drying to obtain the heterogeneously catalyzed 2-trifluoromethyl substituted benzimidazole compound. And carrying out post-treatment to obtain the 2-trifluoromethyl substituted benzimidazole compound. The preparation method has the advantages of mild conditions, simple operation, cheap and easily available initial raw materials and high reaction efficiency; the copper heterogeneous catalyst can be recycled, different functional group substituted trifluoromethyl benzimidazole compounds can be synthesized through substrate design, the operation is convenient, and the applicability of the method is widened.
本发明公开了一种异相催化的2-三氟甲 |
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