CRYSTALLINE FORMS OF 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE AND FORMULATIONS THEREOF

CRYSTALLINE FORMS OF 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE AND FORMULATIONS THEREOF

The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitri...

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Hauptverfasser: MUTZ MICHAEL, MOGI MUNETO, STASI KALI, MORANDI GREGORY, MEDLEY QUINTUS, MAHESHWARI CHINMAY, MONTECCHI-PALMER MICHELA, BULLOCK JOSEPH PAUL, TOWLER CHRISTOPHER STEPHEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile. 本披露提供了4-(7-羟基-2-异丙基-4-氧代-4H-喹唑啉-3-基)-苄腈(化合物I)的多晶型物和配制品。本披露进一步提供了通过施用4-(7-羟基-2-异丙基-4-氧代-4H-喹唑啉-3-基)-苄腈(化合物I)来治疗眼表疼痛的方法。本发明还提供了通过施用4-(7-羟基-2-异丙基-4-氧代-4H-喹唑啉-3-基)-苄腈来治疗干眼病和眼充血的方法。