PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or del...

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Hauptverfasser:	MITCHELL HELEN J, WANG DENGJIN, FORSTER ASHLEY, NANTERMET PHILIPPE, WANG CHENG, FRIE JESSICA L, S. D. KUDOKE, SHA DEYOU, SHIPE WILLIAM DANIEL, CONVERSO ANTONELLA, EL MARROUNI ABDELLATIF, HUNTER DAVID N
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC). 本公开涉及式I的嘧啶酮衍生物以及它们用于选择性杀死HIV感染的GAG-POL表达细胞而不伴随对HIV原初细胞的细胞毒性和用于治疗或预防HIV感染或用于治疗、预防AIDS或AIDS相关综合征(ARC)或延迟AIDS或AIDS相关综合征(ARC)的发作或进展的用途。