SUSTAINED-RELEASE INJECTABLE ANTIBIOTICAL FORMULATION
Provided herein are compositions of injectable antibiotics for veterinary use. The compositions are characterized by forming a gel at animal physiological temperature, said gel being characterized by a stable and repeatable release profile of the antibiotic. The compositions comprise high loading of...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | Provided herein are compositions of injectable antibiotics for veterinary use. The compositions are characterized by forming a gel at animal physiological temperature, said gel being characterized by a stable and repeatable release profile of the antibiotic. The compositions comprise high loading of drug in poloxamer solutions with addition of a co-solvent, and preferably with an addition of a cellulose derivative at least partially soluble in organic solvents. Methods of treatment of veterinary infections are also provided.
本文提供了兽用可注射抗生素组合物。所述组合物的特征在于在动物生理温度下形成凝胶,所述凝胶的特征在于所述抗生素的稳定且可重复的释放概况。所述组合物包含在泊洛沙姆溶液中的高负载量的药物,所述泊洛沙姆溶液添加有助溶剂,并且优选地添加有至少部分溶于有机溶剂的纤维素衍生物。还提供了兽感染的治疗方法。 |
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