Method for preparing guaipyridine type sesquiterpenoid alkaloid

Method for preparing guaipyridine type sesquiterpenoid alkaloid

The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric tot...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ZHANG CUN, AJIAIKEBAIER AISA, WANG BIANLIN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator ZHANG CUN
AJIAIKEBAIER AISA
WANG BIANLIN
description The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric total synthesis of rupestine D and guaipyridine is realized. The method has the characteristic of flexible divergent synthesis, and provides a new way for subsequent screening of compounds with better biological activity. Rupestine D and guaipydine, which are obtained by the method, are subjected to optical rotation, nuclear magnetic data, high-resolution mass spectrum, single crystal and other contrasts with a naturally separated sample, so that the chemical structure and the spatial configuration of the rupestine D and guaipydine are determined. 本发明涉及一种制备愈创吡啶型倍半萜类生物碱的方法，该方法通过改变中间体的片段和后续官能团的改变，得到多个愈创吡啶型倍半萜类生物碱，实现了一枝蒿碱D（rupestine D）和依兰香碱（guaipydine）的不对称全合成。该方法具有灵活的发散式的合成特点，为后续筛选具有更好的生物活性的化合物提供了一种新的途径。通过该方法获得的一枝蒿碱D（rup
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN113402461A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN113402461A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN113402461A3</originalsourceid><addsrcrecordid>eNrjZLD3TS3JyE9RSMsvUigoSi1ILMrMS1dIL03MLKgsykzJzEtVKKksSFUoTi0uLM0sSS0qSM3Lz0xRSMzJTswBMngYWNMSc4pTeaE0N4Oim2uIs4duakF-fGpxQWJyal5qSbyzn6GhsYmBkYmZoaMxMWoA74Uxsw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method for preparing guaipyridine type sesquiterpenoid alkaloid</title><source>esp@cenet</source><creator>ZHANG CUN ; AJIAIKEBAIER AISA ; WANG BIANLIN</creator><creatorcontrib>ZHANG CUN ; AJIAIKEBAIER AISA ; WANG BIANLIN</creatorcontrib><description>The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric total synthesis of rupestine D and guaipyridine is realized. The method has the characteristic of flexible divergent synthesis, and provides a new way for subsequent screening of compounds with better biological activity. Rupestine D and guaipydine, which are obtained by the method, are subjected to optical rotation, nuclear magnetic data, high-resolution mass spectrum, single crystal and other contrasts with a naturally separated sample, so that the chemical structure and the spatial configuration of the rupestine D and guaipydine are determined. 本发明涉及一种制备愈创吡啶型倍半萜类生物碱的方法，该方法通过改变中间体的片段和后续官能团的改变，得到多个愈创吡啶型倍半萜类生物碱，实现了一枝蒿碱D（rupestine D）和依兰香碱（guaipydine）的不对称全合成。该方法具有灵活的发散式的合成特点，为后续筛选具有更好的生物活性的化合物提供了一种新的途径。通过该方法获得的一枝蒿碱D（rup</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210917&amp;DB=EPODOC&amp;CC=CN&amp;NR=113402461A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210917&amp;DB=EPODOC&amp;CC=CN&amp;NR=113402461A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG CUN</creatorcontrib><creatorcontrib>AJIAIKEBAIER AISA</creatorcontrib><creatorcontrib>WANG BIANLIN</creatorcontrib><title>Method for preparing guaipyridine type sesquiterpenoid alkaloid</title><description>The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric total synthesis of rupestine D and guaipyridine is realized. The method has the characteristic of flexible divergent synthesis, and provides a new way for subsequent screening of compounds with better biological activity. Rupestine D and guaipydine, which are obtained by the method, are subjected to optical rotation, nuclear magnetic data, high-resolution mass spectrum, single crystal and other contrasts with a naturally separated sample, so that the chemical structure and the spatial configuration of the rupestine D and guaipydine are determined. 本发明涉及一种制备愈创吡啶型倍半萜类生物碱的方法，该方法通过改变中间体的片段和后续官能团的改变，得到多个愈创吡啶型倍半萜类生物碱，实现了一枝蒿碱D（rupestine D）和依兰香碱（guaipydine）的不对称全合成。该方法具有灵活的发散式的合成特点，为后续筛选具有更好的生物活性的化合物提供了一种新的途径。通过该方法获得的一枝蒿碱D（rup</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD3TS3JyE9RSMsvUigoSi1ILMrMS1dIL03MLKgsykzJzEtVKKksSFUoTi0uLM0sSS0qSM3Lz0xRSMzJTswBMngYWNMSc4pTeaE0N4Oim2uIs4duakF-fGpxQWJyal5qSbyzn6GhsYmBkYmZoaMxMWoA74Uxsw</recordid><startdate>20210917</startdate><enddate>20210917</enddate><creator>ZHANG CUN</creator><creator>AJIAIKEBAIER AISA</creator><creator>WANG BIANLIN</creator><scope>EVB</scope></search><sort><creationdate>20210917</creationdate><title>Method for preparing guaipyridine type sesquiterpenoid alkaloid</title><author>ZHANG CUN ; AJIAIKEBAIER AISA ; WANG BIANLIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113402461A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG CUN</creatorcontrib><creatorcontrib>AJIAIKEBAIER AISA</creatorcontrib><creatorcontrib>WANG BIANLIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG CUN</au><au>AJIAIKEBAIER AISA</au><au>WANG BIANLIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for preparing guaipyridine type sesquiterpenoid alkaloid</title><date>2021-09-17</date><risdate>2021</risdate><abstract>The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric total synthesis of rupestine D and guaipyridine is realized. The method has the characteristic of flexible divergent synthesis, and provides a new way for subsequent screening of compounds with better biological activity. Rupestine D and guaipydine, which are obtained by the method, are subjected to optical rotation, nuclear magnetic data, high-resolution mass spectrum, single crystal and other contrasts with a naturally separated sample, so that the chemical structure and the spatial configuration of the rupestine D and guaipydine are determined. 本发明涉及一种制备愈创吡啶型倍半萜类生物碱的方法，该方法通过改变中间体的片段和后续官能团的改变，得到多个愈创吡啶型倍半萜类生物碱，实现了一枝蒿碱D（rupestine D）和依兰香碱（guaipydine）的不对称全合成。该方法具有灵活的发散式的合成特点，为后续筛选具有更好的生物活性的化合物提供了一种新的途径。通过该方法获得的一枝蒿碱D（rup</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN113402461A
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Method for preparing guaipyridine type sesquiterpenoid alkaloid
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T14%3A55%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHANG%20CUN&rft.date=2021-09-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN113402461A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true