Method for preparing guaipyridine type sesquiterpenoid alkaloid

The invention relates to a method for preparing guaipyridine type sesquiterpenoid alkaloids. The method is characterized in that a plurality of guaipyridine type sesquiterpenoid alkaloids are obtained by changing segments of intermediates and changing subsequent functional groups, and asymmetric total synthesis of rupestine D and guaipyridine is realized. The method has the characteristic of flexible divergent synthesis, and provides a new way for subsequent screening of compounds with better biological activity. Rupestine D and guaipydine, which are obtained by the method, are subjected to optical rotation, nuclear magnetic data, high-resolution mass spectrum, single crystal and other contrasts with a naturally separated sample, so that the chemical structure and the spatial configuration of the rupestine D and guaipydine are determined. 本发明涉及一种制备愈创吡啶型倍半萜类生物碱的方法，该方法通过改变中间体的片段和后续官能团的改变，得到多个愈创吡啶型倍半萜类生物碱，实现了一枝蒿碱D（rupestine D）和依兰香碱（guaipydine）的不对称全合成。该方法具有灵活的发散式的合成特点，为后续筛选具有更好的生物活性的化合物提供了一种新的途径。通过该方法获得的一枝蒿碱D（rup