Synthesis method of (E)-beta-fluoroacrylamide derivative

The invention relates to a synthesis method of an (E)-beta-fluoroacrylamide derivative, which comprises the following steps: by taking trifluoroacrylamide and a boric acid derivative as substrates, palladium acetate as a catalyst, triphenylphosphine as a ligand and potassium carbonate as alkali, stirring and reacting for 12 hours at 60-100 DEG C in an ultra-dry toluene solvent in a nitrogen atmosphere; the method has the advantages that the raw materials are simple and easy to obtain, the reaction operation is simple, the conditions are relatively mild, the substrate universality is wide, the yield is relatively high, and the functional group compatibility is good. 本发明涉及一种(E)-β-氟丙烯酰胺衍生物的合成方法，包括以下步骤：以三氟丙烯酰胺和硼酸衍生物为底物，醋酸钯作催化剂，三苯基膦作配体，碳酸钾作碱，在超干的甲苯溶剂中，氮气氛围下，于60-100oC搅拌反应12小时。本发明具有原料简单易得，反应操作简单、条件相对温和、底物普适性广、产率较高、官能团兼容性良好的优点。