Programmable controlled release temperature response type hydrogel capsule shell and preparation method thereof

The invention provides a programmable controlled release temperature response type hydrogel capsule shell. The capsule shell is integrated and is prepared through 3D printing, and a preparation method of the used raw materials comprises the following steps of adding NIPAM, PEGDA, N, N-methylene bisacrylamide and alpha-ketoglutaric acid into pure water according to a molar ratio of 5000: 830: 1: 10 to obtain a solution, then adding a pore-foaming agent accounting for 0.01-60% (m/v) of the total volume of the solution, uniformly mixing, carrying out vacuum degassing under stirring, adding a rheology modifier, and fully stirring to obtain a capsule shell raw material. The drug release curve is programmed through the molecular weight and content of the pore-foaming agent and the release temperature of the hydrogel capsule shell material, and the capsule shell has high environmental stimulation response. 本发明提供一种可编程控释的温度响应型水凝胶胶囊壳，胶囊壳为一体型，通过3D打印制备得到，所使用的原料的制备方法如下：将NIPAM、PEGDA、N,N-亚甲基双丙烯酰胺和α-酮戊二酸按摩尔比5000:830:1:10加入纯水