METHOD FOR THE MANUFACTURE OF 4-NITRO-N-(C1-8 ALKYL)PHTHALIMIDE

A method for the manufacture of 4-nitro-N-(C1-8 alkyl)phthalimide includes providing a first stream having a solution of a N-(C1-8 alkyl)phthalimide and sulfuric acid; and a second stream including nitric acid and sulfuric acid to a micro-reactor under conditions effective to provide a product strea...

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Hauptverfasser:	PANDEY SATISH CHANDRA, GUGGENHEIM THOMAS LINK, BALAKRISHNAN GANESAN, LAKHETE PRASHIL, SREERAMAGIRI SIVAKUMAR
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Zusammenfassung:	A method for the manufacture of 4-nitro-N-(C1-8 alkyl)phthalimide includes providing a first stream having a solution of a N-(C1-8 alkyl)phthalimide and sulfuric acid; and a second stream including nitric acid and sulfuric acid to a micro-reactor under conditions effective to provide a product stream including 4-nitro-N-(C1-8 alkyl)phthalimide. A method for the manufacture of 4-nitro-N-(C1-8 alkyl)phthalimide can include providing a first stream having a molten N-(C1-8 alkyl)phthalimide; and a second stream consisting of nitric acid; to a micro-reactor under conditions effective to provide a product stream including 4-nitro-N-(C1-8 alkyl)phthalimide Advantageously, 4-nitro-N-(C1-8 alkyl)phthalimide obtained by the process can have reduced levels of di-nitro byproducts. 一种用于制备4-硝基-N-(C1-8烷基)邻苯二甲酰亚胺的方法，包括在有效提供包含4-硝基-N-(C1-8烷基)邻苯二甲酰亚胺的产物料流的条件下向微反应器中提供具有N-(C1-8烷基)邻苯二甲酰亚胺和硫酸的溶液的第一料流；以及包含硝酸和硫酸的第二料流。一种用于制备4-硝基-N-(C1-8烷基)邻苯二甲酰亚胺的方法，可以包括在有效提供包含4-硝基-N-(C1-8烷基)邻苯二甲酰亚胺的产物料流的条件下向微反应器中提供具有熔融N-(C1-8烷基)邻苯二甲酰亚胺的第一料流；和由硝酸组成的第二