Recombinant bovine nodule rash virus for expressing bovine herpesvirus I type gB gene and application of recombinant bovine nodule rash virus

The invention relates to the technical field of biology, and particularly provides a recombinant bovine nodule rash virus for expressing a bovine herpesvirus I type gB gene and application of the recombinant bovine nodule rash virus. The recombinant bovine nodule rash virus contains the bovine herpes virus I type gB gene as shown in SEQ ID NO.1. The recombinant bovine nodule rash virus has antigen epitopes of the two viruses, so that direct inoculation can be realized by using the virus as a live vector vaccine, operations such as inactivation and adjuvant emulsification are avoided, and the recombinant bovine nodule rash virus has good immunogenicity on bovine nodule rash virus and infectious bovine rhinotracheitis virus, and two prevention by one injection is achieved. 本发明涉及生物技术领域，具体而言，提供了一种表达牛疱疹病毒Ⅰ型gB基因的重组牛结节疹病毒及其应用。本发明提供的重组牛结节疹病毒，其中含有SEQ ID NO.1所示的牛疱疹病毒Ⅰ型gB基因，该病毒兼具两种病毒的抗原表位，以此作为活载体疫苗可以实现直接接种，避免了灭活、佐剂乳化等操作，对牛结节疹病毒和牛传染性鼻气管炎病毒均具有良好的免疫原性，实现"一针两防"。