High-purity D-dihydrophenylglycine methyl ester and preparation method thereof

The invention discloses high-purity D-dihydrophenylglycine methyl ester and a preparation method thereof, and belongs to the field of pharmaceutical chemicals, and the preparation method comprises the following steps: uniformly mixing and stirring D-dihydrophenylglycine and methanol, carrying out heating reflux, adding a reaction reagent concentrated sulfuric acid or thionyl chloride, and carrying out reflux reaction to obtain the high-purity D-dihydrophenylglycine methyl ester. According to the preparation method, the existing preparation process is changed, the content of phenylglycine methyl ester in the product is less than 0.67%, and due to the innovative preparation mode, the product cost is reduced. In addition, the production process is simple and easy to operate, low in production cost and beneficial to industrial production. 本发明公开了一种高纯度D-二氢苯基甘氨酸甲酯及其制备方法，属于医药化工领域，制备方法包括D-二氢苯基甘氨酸与甲醇混合搅拌均匀，加热回流，加入反应试剂浓硫酸或氯化亚砜，回流反应，高纯度D-二氢苯基甘氨酸甲酯。本发明的制备方法改变了现有的制备工艺，使产品的苯基甘氨酸甲酯在0.67％以下，由于创新了制备方式，使产品成本有所下降。此外，生产工艺简便易操作，生产