Application of trans-cinnamaldehyde and derivatives thereof as histone deacetylase agonist

The invention discloses application of trans-cinnamaldehyde and derivatives thereof as a histone deacetylase agonist. According to the application, firstly, a target of trans-cinnamaldehyde in a mouse body is predicted through Target Hunter software, a prediction result indicates that trans-cinnamaldehyde is related to combination of histone deacetylase (HDAC), and it is indicated that the acting target of trans-cinnamaldehyde in the body is possibly deacetylase. Subsequently, the influence of trans-cinnamaldehyde and derivatives thereof on the activity of histone deacetylase 6 is detected through in-vitro experiments, and it is proved that trans-cinnamaldehyde has an activation effect on HDAC6 within a certain concentration range (a is larger than or equal to 10 nM and smaller than or equal to 100 nM). Finally, human umbilical vein endothelial cells, rat myocardial cells H9C2 and human renal epithelial 293T cells are incubated together with trans-cinnamaldehyde, alpha-methyl-trans-cinnamaldehyde, alpha-hexyl