Lactobacillus fermentation lysate, preparation method, application and skin external preparation containing lactobacillus fermentation lysate

The invention discloses a lactobacillus fermentation lysate, a preparation method, application and a skin external preparation containing the lactobacillus fermentation lysate. The preparation method of the lactobacillus fermentation lysate comprises the following steps of inoculating lactobacillus into a fermentation substrate, and carrying out fermentation culture, ultrasonic treatment and sterilization, thereby obtaining the lactobacillus fermentation lysate, wherein the fermentation substrate comprises raw milk. The lactobacillus fermentation lysate prepared by the method has the effects of resisting oxidation, protecting and repairing human skin fibroblasts, improving collagen generation, preserving moisture and the like, is high in safety, simple and easily available in raw materials and low in preparation cost, and can be widely applied to the field of cosmetics. 本发明公开了一种乳酸菌发酵溶胞物、制备方法、应用及含其的皮肤外用剂。乳酸菌发酵溶胞物的制备方法包括如下步骤：乳酸菌接种到发酵底物中，经发酵培养、超声、灭菌，即可；其中，发酵底物包括原料乳。本发明制得的乳酸菌发酵溶胞物同时兼具抗氧化、保护和修复人皮肤成纤维细胞、提高胶原蛋白生成和保湿