PH-responsive double-drug sustained-release particles

The invention belongs to the field of drug sustained-release body materials, and particularly relates to pH-responsive double-drug sustained-release body particles and a preparation method thereof. The pH-responsive double-drug sustained-release particles are PDBA modified mesoporous hydroxyapatite...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LIAO XIUPING, WANG JING, ZHANG YIJIE, XIANG YANG, ZHENG JIANNAN, MEI DAN, MA KUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention belongs to the field of drug sustained-release body materials, and particularly relates to pH-responsive double-drug sustained-release body particles and a preparation method thereof. The pH-responsive double-drug sustained-release particles are PDBA modified mesoporous hydroxyapatite loaded with enoxacin and simvastatin, and by grafting PDBA, the control on drug loading and release in different pH environments is realized. 本发明属于药物缓释体材料领域，具体涉及一种pH响应性双药物缓释体颗粒及其制备方法。所述pH响应性双药物缓释体颗粒是一种负载了依诺沙星和辛伐他汀的PDBA修饰的介孔羟基磷灰石，通过接枝PDBA，实现了在不同pH环境下对药物负载和释放的控制。