Broad-spectrum anti-inflammatory polypeptide compound with NMDA and p55PIK as targets and preparation method and application thereof

The invention discloses a broad-spectrum anti-inflammatory polypeptide compound with NMDA and p55PIK as targets and a preparation method and application thereof. The broad-spectrum anti-inflammatory polypeptide compound comprises an active peptide fragment, the amino acid sequence of the active peptide fragment is MMTYSTELIFYIEMDP or MMTYSTELIFYIEMDPG, the broad-spectrum anti-inflammatory polypeptide compound further comprises a transmembrane structure or fatty acid loaded at the N-terminal of the active peptide fragment, the fatty acid is capric acid, lauric acid or palmitic acid, the polypeptide compound with the structure is a non-steroidal inhibitor, taking a PI3K subtype member, p55PIK, as a target can effectively inhibit the occurrence of inflammation, the saturated fatty acid is connected to the N-terminal, so as to be able to effectively help an active region to penetrate through a cell membrane, reach a target site and exert effects, bridging polyethylene glycol can enhance polarity to be easy to pen