Microsphere adsorbent for removing toxins through blood perfusion and preparation method of microsphere adsorbent

The invention belongs to the technical field of adsorbents for blood perfusion, and discloses a microsphere adsorbent for removing toxins in blood perfusion and a preparation method of the microsphere adsorbent. According to the microsphere adsorbent, crosslinked polystyrene-divinyl benzene microspheres serve as carriers, polymyxin B is connected to the surfaces of the microspheres, and the microspheres are connected with the polymyxin B through molecular arms; and the molecular arm is 11-mercaptoundecanoic acid or 3-mercaptopropionic acid. The invention also discloses a preparation method of the microsphere adsorbent. The microsphere adsorbent disclosed by the invention has relatively good adsorption performance on bilirubin and endotoxin, has good blood compatibility and can be used for relatively well removing toxins in blood. 本发明属于血液灌流用吸附剂的技术领域，公开了用于血液灌流去除毒素的微球吸附剂及其制备方法。所述微球吸附剂是以交联聚苯乙烯-二乙烯基苯微球为载体，表面接有多粘菌素B，微球与多粘菌素B通过分子臂相连；所述分子臂为11-巯基十一酸或3-巯基丙酸。本发明还公开了微球吸附剂的制备方法。本发明的微球吸附剂对胆红素和内毒素具有较好的吸附性能，并具有良好的血液相容性，能较好的去