METHOD FOR CONTINUOUSLY PREPARING 5-CITALOPRAM DIOL

The present application relates to a method for citalopram intermediate 5-citalopram diol. The method comprises firstly mixing two Grignard reagents required for a reaction; then mixing the mixed Grignard reagents with a raw material 5-cyanophthalide in a temperature-controllable micromixer to obtain a reaction solution; then subjecting the reaction solution to the reaction by means of a reactor to obtain a 5-citalopram diol reaction solution; and then performing operations such as quenching, concentration, extraction, acidification, and crystallization to obtain a qualified product. The 5-citalopram diol provided in the present invention has good selectivity, high yield, high safety, safety and reliability, and little sewage discharge, and is suitable for industrial production. 本申请涉及一种连续制备西酞普兰中间体5-氰二醇的方法，所述方法包括将反应所需两种格氏试剂优先混合，再将混合好的格氏试剂与原料5-氰基苯酞在可控温微混合器中进行混合得到反应液，再将反应液通过反应器完成反应，得到5-氰二醇反应液，再经淬灭、浓缩、提取、酸化、结晶等操作得到合格产品。本发明提供的5-氰二醇选择性好、收率高、安全性高、安全可靠、排污少适合工业化生产。