Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles

The invention discloses a method for improving the dissolution rate of triclabendazole particles and a dissolution rate detection method of the triclabendazole particles. The method comprises the following steps: firstly, mixing water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 ac...

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Hauptverfasser: CHEN YUQING, LIU JINGJING, HU GUOBIN, XIA WEI, XIAO XINGLI, XIAO XINGE, TANG JINBO, CHEN QIJIE, ZHOU ZILONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for improving the dissolution rate of triclabendazole particles and a dissolution rate detection method of the triclabendazole particles. The method comprises the following steps: firstly, mixing water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 according to a ratio of 3: 6: 0.4: 0.6, stirring and dissolving to obtain a clear and uniform composite solution for later use; then mixing triclabendazole, starch and glucose in a high-speed mixing pot according to a ratio of 1: 1: 8 for 5 minutes, slowly adding the mixture into the composite solution in the step S1 according to a ratio of 5% by adopting a method of stirring while adding, and then mixing for 5-10 minutes to prepare a soft material; and finally, feeding the soft material to a granulator, granulating with a 18-mesh screen, collecting, and drying in a drying oven. Compared with the prior art, the method for preparing the triclabendazole granules by using the composite solution has the advantages that t