1-alkynyl tetrahydroisoquinoline compound and preparation method thereof

The invention is suitable for the technical field of compounds, and provides a 1-alkynyl tetrahydroisoquinoline compound and a preparation method thereof. The preparation method of the 1-alkynyl tetrahydroisoquinoline compound comprises the steps that a cadmium catalyst, a tetrahydroisoquinoline compound, an alkyne derivative, an organic solvent and an oxidizing agent are sequentially added into a reaction container, and carrying out an oil bath stirring reaction at the temperature of 100-110 DEG C, and carrying out filtration, elution and reduced pressure distillation treatment to obtain the 1-alkynyl tetrahydroisoquinoline compound. By using the cheap cadmium metal catalyst, the high yield of the 1-alkynyl tetrahydroisoquinoline compound is obtained while the preparation process is simplified, and the problems of high catalyst price, heavy metal residue and the like in the current preparation process of the 1-alkynyl tetrahydroisoquinoline compound are solved; convenient and green preparation of the 1-alkyn