Class II histocompatibility complex expression enhancing compound and preparation method and application thereof
The invention discloses a class II histocompatibility complex (MHC class II) expression enhancing compound and a preparation method and application thereof. Experiments prove that the compound has a remarkable class II histocompatibility complex expression enhancing effect, remarkable effect in enha...
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| creator | TED WEI LI LULU XIE LANGUI HUANG LING CHEN LIMING |
| description | The invention discloses a class II histocompatibility complex (MHC class II) expression enhancing compound and a preparation method and application thereof. Experiments prove that the compound has a remarkable class II histocompatibility complex expression enhancing effect, remarkable effect in enhancing class II histocompatibility complex tumor neoantigen presentation and promoting tumor tissue CD4 + T cell infiltration, and remarkable effect in inhibiting tumor growth when the compound is used independently or combined with existing immunotherapy means drugs.
本发明公开了一种Ⅱ类组织相容性复合体(MHC classⅡ)表达增强化合物、其制备方法及应用，本申请通过实验验证，所述化合物对Ⅱ类组织相容性复合体(MHC classⅡ)表达增强效果显著，对增强Ⅱ类组织相容性复合体肿瘤新生抗原呈递促进肿瘤组织CD4+T细胞侵润效果显著，单独或与现有免疫治疗手段药物联用对肿瘤生长抑制效果显著。 |
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本发明公开了一种Ⅱ类组织相容性复合体(MHC classⅡ)表达增强化合物、其制备方法及应用，本申请通过实验验证，所述化合物对Ⅱ类组织相容性复合体(MHC classⅡ)表达增强效果显著，对增强Ⅱ类组织相容性复合体肿瘤新生抗原呈递促进肿瘤组织CD4+T细胞侵润效果显著，单独或与现有免疫治疗手段药物联用对肿瘤生长抑制效果显著。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210827&DB=EPODOC&CC=CN&NR=113307737A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76292</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210827&DB=EPODOC&CC=CN&NR=113307737A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TED WEI</creatorcontrib><creatorcontrib>LI LULU</creatorcontrib><creatorcontrib>XIE LANGUI</creatorcontrib><creatorcontrib>HUANG LING</creatorcontrib><creatorcontrib>CHEN LIMING</creatorcontrib><title>Class II histocompatibility complex expression enhancing compound and preparation method and application thereof</title><description>The invention discloses a class II histocompatibility complex (MHC class II) expression enhancing compound and a preparation method and application thereof. Experiments prove that the compound has a remarkable class II histocompatibility complex expression enhancing effect, remarkable effect in enhancing class II histocompatibility complex tumor neoantigen presentation and promoting tumor tissue CD4 + T cell infiltration, and remarkable effect in inhibiting tumor growth when the compound is used independently or combined with existing immunotherapy means drugs.
本发明公开了一种Ⅱ类组织相容性复合体(MHC classⅡ)表达增强化合物、其制备方法及应用，本申请通过实验验证，所述化合物对Ⅱ类组织相容性复合体(MHC classⅡ)表达增强效果显著，对增强Ⅱ类组织相容性复合体肿瘤新生抗原呈递促进肿瘤组织CD4+T细胞侵润效果显著，单独或与现有免疫治疗手段药物联用对肿瘤生长抑制效果显著。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi8EKwjAQRHvxIOo_xA8QLDn0LEWxF0_eyxq3ZiHNLtkI9e-N1g_wMAzzZmZZSRtA1XSd8aSZHY8CmW4UKL_MJwWcDE6SUJU4GoweoqP4-Jb8jHcDRaUXSOVZJiNmzzMGkUBuxtljQh7W1WKAoLj5-arano7X9rxD4R5VwGHE3LeXurZ23zS2Odh_Nm_ofERl</recordid><startdate>20210827</startdate><enddate>20210827</enddate><creator>TED WEI</creator><creator>LI LULU</creator><creator>XIE LANGUI</creator><creator>HUANG LING</creator><creator>CHEN LIMING</creator><scope>EVB</scope></search><sort><creationdate>20210827</creationdate><title>Class II histocompatibility complex expression enhancing compound and preparation method and application thereof</title><author>TED WEI ; LI LULU ; XIE LANGUI ; HUANG LING ; CHEN LIMING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113307737A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TED WEI</creatorcontrib><creatorcontrib>LI LULU</creatorcontrib><creatorcontrib>XIE LANGUI</creatorcontrib><creatorcontrib>HUANG LING</creatorcontrib><creatorcontrib>CHEN LIMING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TED WEI</au><au>LI LULU</au><au>XIE LANGUI</au><au>HUANG LING</au><au>CHEN LIMING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Class II histocompatibility complex expression enhancing compound and preparation method and application thereof</title><date>2021-08-27</date><risdate>2021</risdate><abstract>The invention discloses a class II histocompatibility complex (MHC class II) expression enhancing compound and a preparation method and application thereof. Experiments prove that the compound has a remarkable class II histocompatibility complex expression enhancing effect, remarkable effect in enhancing class II histocompatibility complex tumor neoantigen presentation and promoting tumor tissue CD4 + T cell infiltration, and remarkable effect in inhibiting tumor growth when the compound is used independently or combined with existing immunotherapy means drugs.
本发明公开了一种Ⅱ类组织相容性复合体(MHC classⅡ)表达增强化合物、其制备方法及应用，本申请通过实验验证，所述化合物对Ⅱ类组织相容性复合体(MHC classⅡ)表达增强效果显著，对增强Ⅱ类组织相容性复合体肿瘤新生抗原呈递促进肿瘤组织CD4+T细胞侵润效果显著，单独或与现有免疫治疗手段药物联用对肿瘤生长抑制效果显著。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Class II histocompatibility complex expression enhancing compound and preparation method and application thereof |
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