Preparation method and application of targeted mercuric sulfide nanoparticle medicine

The invention discloses a preparation method of a targeted mercuric sulfide nanoparticle medicine. Mercuric sulfide nanoparticles are prepared by applying a one-pot method and taking mercuric nitrate and sodium sulfide as raw materials and reducing glutathione as a protective agent and a modifier, the whole preparation process is simple, the process is controllable, the period is short, the prepared mercuric sulfide nanoparticles are uniform in particle size, the particle size is within 12nm, the skin targeting effect is realized in the practical application of psoriasis treatment, the acting time of the medicine on the skin surface is remarkably prolonged, and the toxic and side effects of the medicine on non-targeting parts are greatly reduced. The preparation method is suitable for preparing the targeted mercuric sulfide nano-particle medicine, and further preparing a gel ointment containing the targeted mercuric sulfide nano-particle medicine. 本发明公开了一种靶向型硫化汞纳米颗粒药物的制备方法，应用一锅法并以硝酸汞、硫化钠为原料，还原性谷胱甘肽为保护剂及修饰剂制备硫