Cyclic Ureas

Amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition. 抑制细胞坏死和/或人受体相互作用蛋白1激酶(RIP1)的酰胺及其药学上可接受的盐、水合物和立体异构体，所述酰胺包括相应的磺酰胺。这些化合物被应用于药物组合物、制备和使用方法中，所述方法包括用有效量的化合物或组合物治疗有其需要的人，以及检测产生的对该人的健康或病症的改善。