COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING FIBROSIS

The present application relates to compositions and methods for treating and preventing fibrosis and other diseases comprising a polypeptide derived from MFG-E8 wherein the polypeptide comprises an epidermal growth factor (EGF)-like domain, a C1 domain, and optionally a signal peptide, wherein the p...

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Bibliographische Detailangaben
Hauptverfasser:	YOO TACK-JIN, HAN CHOONG-SEONG, KIM WOONG, AN GEUN-HO, JEONG JIN-WOO, LEE JAE-HUN, WOO DONG-HUN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to compositions and methods for treating and preventing fibrosis and other diseases comprising a polypeptide derived from MFG-E8 wherein the polypeptide comprises an epidermal growth factor (EGF)-like domain, a C1 domain, and optionally a signal peptide, wherein the polypeptide: (a) lacks a functional C2 domain; and/or (b) lacking a medin polypeptide or fragment thereof. 本申请涉及用于治疗和预防纤维化和其他疾病的包括源自MFG-E8的多肽的组合物和方法，其中所述多肽包含表皮生长因子(EGF)样域、C1域、以及可选的信号肽，其中所述多肽：(a)缺少功能性C2域；和/或(b)缺少medin多肽或其片段。