3-(4-methylpiperidin-1-yl)-3-benzyl urea compound and analogues thereof, preparation method and application

The invention discloses a 3-(4-methylpiperidin-1-yl)-3-benzyl urea compound and analogues thereof, a preparation method and application, belongs to the technical field of medicines, and particularly relates to preparation of the 3-(4-methylpiperidin-1-yl)-3-benzyl urea compound and analogues thereof and application of the 3-(4-methylpiperidin-1-yl)-3-benzyl urea compound and analogues thereof in preparation of antitumor drugs. The structural general formula of the 3-(4-methylpiperidin-1-yl)-3-benzylurea compound and analogues thereof is as shown in formula I, n is equal to 0-2, R1 and R2 are respectively and independently methoxy, ethyoxyl, isobutoxy, fluorine, chlorine, 2-(1-methylpiperazin-4-yl)ethyoxyl or trifluoromethoxy, and R3 and R4 are respectively and independently hydrogen or 1-methylpiperazin-4-yl. The synthesis method of the compound is simple and convenient, the compound is suitable for industrial production, and biological activity tests show that the compound has anti-tumor activity and is appl