Application of recombinant cytokine gene derived protein or fragment thereof

The invention provides an application of a recombinant cytokine gene-derived protein or a fragment thereof in inhibiting the activity of a coronaviridae virus. The recombinant cytokine gene-derived protein comprises an amino acid sequence SEQ ID NO: 1, or an amino acid sequence having at least 90% identity with the amino acid sequence SEQ ID NO: 1. In addition, the invention also provides application of the recombinant cytokine gene derived protein or the fragment thereof in preparation of drugs for preventing or treating diseases or symptoms related to coronaviridae viruses in subjects. The recombinant cytokine gene derived protein or fragment thereof according to the present invention has enhanced anti-coronaviridae virus activity compared to human interferon [alpha]2b (HuIFN-[alpha]2b). 本发明提供了一种重组细胞因子基因衍生蛋白或其片段在用于抑制冠状病毒科病毒活性中的用途，其中所述重组细胞因子基因衍生蛋白包含氨基酸序列SEQ ID NO：1、或与氨基酸序列SEQ ID NO：1具有至少90％同一性的氨基酸序列。另外，本发明还提供了上述重组细胞因子基因衍生蛋白或其片段在制备用于预防或治疗受试者中与冠状病毒科病毒相关的疾病或症状的药物中的用途。根据本发明的重组细胞因子基因衍生蛋白或其片段具有相比人干扰素α2b(HuIFN-α2b)