Application of erianin in preparation of osteoclast differentiation inhibitor

The invention relates to application of erianin in preparation of an osteoclast differentiation inhibitor. Experiments prove that low-dose erianin can significantly inhibit RANKL and breast cancer induced mouse osteoclast generation and bone resorption activity; meanwhile, low-dose erianin can inhibit osteoclast precursor cells of a patient with breast cancer bone metastasis from generating polykaryotic osteoclasts, so that erianin can be used as an osteoclast differentiation inhibitor drug for treating diseases by an osteoclast differentiation inhibitor. The invention provides a new application of erianin, and also provides a new thought for treating bone destruction related diseases, tumor-induced bone destruction and other diseases. 本发明涉及毛兰素在制备破骨细胞分化抑制剂中的应用。本发明经过试验证明，低剂量毛兰素能显著抑制RANKL及乳腺癌诱导的小鼠破骨细胞生成和骨吸收活性；同时低剂量毛兰素可抑制乳腺癌骨转移病人的破骨前体细胞生成多核破骨细胞，使其可以作为一个破骨细胞分化抑制剂类药物，用于破骨细胞分化抑制剂所治疗疾病。本发明为毛兰素提供了一种新用途，也为骨破坏相关疾病及肿瘤诱导骨破坏等疾病的治疗提供了新的思路。