Astaxanthin amorphous solid dispersion prepared by electrostatic spraying method and preparation method thereof

The invention discloses an astaxanthin amorphous solid dispersion prepared by an electrostatic spraying method and a preparation method thereof, and relates to the field of insoluble drug nano preparations. An amphiphilic block copolymer and a hydrophilic high-molecular polymer are used as co-spraying carriers and dissolved in a mixed solvent of dichloromethane and methanol, and the astaxanthin amorphous solid dispersion with the rapid release characteristic is prepared through an electrostatic spraying method. The mass ratio of the astaxanthin to the amphiphilic block copolymer to the hydrophilic high-molecular polymer is 1: (6-24): (4-8), the mass volume concentration of the astaxanthin in the mixed solvent is 0.05%-0.3% (w/v), the concentration of the amphiphilic block copolymer in the mixed solvent is 0.3%-4.8% (w/v), and the concentration of the hydrophilic high-molecular polymer in the mixed solvent is 0.2%-2.4% (w/v). The preparation can improve the solubility of astaxanthin, promote drug release and i