Preparation method of pH-responsive organic-inorganic composite bone cement

The invention discloses a preparation method of pH-responsive organic-inorganic composite bone cement. The method comprises the following steps: reacting calcium ions with carbonate ions to generate pH-responsive calcium carbonate nanoparticles, and adding antibiotics in the preparation process to load the antibiotics in calcium carbonate; by taking drug-loaded calcium carbonate nanoparticles as a core, forming a poly (dimethylaminoethyl methacrylate) hydrogel shell layer on the surface of calcium carbonate, and then washing, freeze-drying and ball-milling to obtain pH response core-shell microspheres; and mixing the pH-responsive core-shell microspheres with polymethyl methacrylate and barium sulfate to obtain a pH-responsive organic-inorganic composite bone cement solid phase, mixing the pH-responsive organic-inorganic composite bone cement solid phase with a liquid phase, stirring, and curing to obtain the pH-responsive organic-inorganic composite bone cement. The problem that the expandable bone cement in