Group of compounds for preparing novel coronavirus inhibitor medicine

The invention belongs to the field of medicines, and particularly relates to a group of compounds for preparing a novel coronavirus inhibitor medicine, specifically 12 kinds of compounds of ZINC96222420, ZINC96222315, ZINC253387805, ZINC970913, ZINC4090409, ZINC824654994, ZINC85593479, ZINC8791993, ZINC32949025, ZINC253387765, ZINC96296478 and ZINC107314 and/or any combination mode of the 12 kinds of compounds. The invention also unexpectedly finds that the combination conformation of the compound ZINC96222420 and an SARS-CoV-2 main protease compound is highly stable; and the compound has great potential as a compound for preparing a COVID-19 resistant medicine. 本发明属于医药领域，具体涉及一组制备新型冠状病毒抑制剂药物所用的化合物。具体为ZINC96222420、ZINC96222315、ZINC253387805、ZINC970913、ZINC4090409、ZINC824654994、ZINC85593479、ZINC8791993、ZINC32949025、ZINC253387765、ZINC96296478和ZINC1073145这12种化合物和/或这12种化合物的任意组合方式。本发明还意料之外的发现了化合物ZINC96222420与SARS-CoV-2主蛋白酶复合物的结合构象高度稳定，该化合物具有作为制备抗新冠肺炎药物的化合物的巨大潜力。