Antigen binding protein neutralizing streptococcus pneumoniae hemolysin protein and use of antigen binding protein

The present application relates to an isolated antigen binding protein comprising HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the HCDR1 comprises an amino acid sequence as shown in SEQ ID NO: 3, the HCDR2 comprises an amino acid sequence as shown in SEQ ID NO: 2, the HCDR3 comprises an amin...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN XINNING, QIU XIRAN, LI BOHUA, GUO SHIYU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application relates to an isolated antigen binding protein comprising HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the HCDR1 comprises an amino acid sequence as shown in SEQ ID NO: 3, the HCDR2 comprises an amino acid sequence as shown in SEQ ID NO: 2, the HCDR3 comprises an amino acid sequence as shown in SEQ ID NO: 1, the LCDR1 comprises an amino acid sequence as shown in SEQ ID NO: 6, the LCDR2 comprises an amino acid sequence as shown in SEQ ID NO: 5, and the LCDR3 comprises an amino acid sequence as shown in SEQ ID NO: 4. The antigen binding protein can be specifically bound with streptococcus pneumoniae hemolysin protein. The invention also provides a preparation method and application of the separated antigen binding protein. 本申请涉及一种分离的抗原结合蛋白，其包含HCDR1，HCDR2，HCDR3，LCDR1，LCDR2和LCDR3，所述HCDR1包含SEQ ID NO:3所示的氨基酸序列，所述HCDR2包含SEQ IDNO:2所示的氨基酸序列，所述HCDR3包含SEQ ID NO:1所示的氨基酸序列，所述LCDR1包含SEQ ID NO:6所示的氨基酸序列，所述LCDR2包含SEQ ID NO:5所示的氨基酸序列，且所述LCDR3包含SEQ ID NO:4所示的氨基酸序列。所述抗原结合蛋白能够特异性结合肺炎链球菌溶血素蛋白。本申请还提