Atropine sulfate eye drops as well as preparation method and application thereof

The invention relates to atropine sulfate eye drops as well as a preparation method and application thereof. The atropine sulfate injection comprises atropine sulfate and a drug release system, also comprises an auxiliary material and/or water for injection, and is characterized by comprising the fo...

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Bibliographische Detailangaben
Hauptverfasser: TAO YIHUA, WEI YAN, LING XIUQUAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to atropine sulfate eye drops as well as a preparation method and application thereof. The atropine sulfate injection comprises atropine sulfate and a drug release system, also comprises an auxiliary material and/or water for injection, and is characterized by comprising the following components: 0.001-0.2 percent (w/v) of atropine sulfate, a tackifier, an osmotic pressure regulator, a metal chelating agent, a preservative, a pH regulator and water for injection. Thickening agents such as polycarbophil, hydroxypropyl methylcellulose and polyvinylpyrrolidone are used as adhesive polymers, so that the retention time of the medicine in eyes is prolonged, the bioavailability of the medicine in the eyes is improved, the irritation to the eyes is small and the absorption of the lacrimal sac to the medicine can be reduced; According to the technical scheme, the side effects of atropine can be relieved, including pupil enlargement, unclear vision of near objects, photophobia, conjunctivitis and