Pyrrolobenzodiazepine dimer compound with improved safety and use thereof

The present invention relates to a novel pyrrolobenzodiazepine dimer compound or a pharmaceutically acceptable salt thereof, a ligand-drug conjugate compound thereof, a composition containing the same, and a therapeutic use thereof as an anticancer agent. The pyrrolobenzodiazepine dimer compound according to the present invention, in the form of a free toxin, exhibits an effect of greatly reducing toxicity due to a drop in activity thereof, and when a ligand-drug conjugate is applied and administered as a drug, has anticancer activity equal or superior to that of an existing anticancer agent and exhibits an effect of having a significantly improved therapeutic index. Therefore, the pyrrolobenzodiazepine dimer compound according to the present invention is very industrially useful, in that targeting of proliferative diseases such as cancer, specific treatment, maximization of drug efficacy, and minimization of the expression of side effects are possible. 本发明涉及新型吡咯并苯并二氮杂二聚体化合物或其药学上可接受的盐、其配体-药物缀合化合物、包含其的组合物以及其作为