RAPAMYCIN DERIVATIVES

The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein. 本披露提供了具有式(I)的32-脱氧-雷帕霉素衍生物或其药学上可接受的盐、包含具有式(I)的化合物的药物组合物和药物组合，及其制备方法。本文还提供了使用具有式(I)的化合物或其药学上可接受的盐治疗本文所述的疾病和障碍的方法。