Nitrosyl ruthenium complex, compound of nitrosyl ruthenium complex and serum protein, preparation methods of nitrosyl ruthenium complex and compound, and application of compound

The invention belongs to the technical field of nitrosyl ruthenium complexes, and provides a nitrosyl ruthenium complex, a compound of the nitrosyl ruthenium complex and serum protein, preparation methods the nitrosyl ruthenium complex and the compound, and application of the compound. The chemical...

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Hauptverfasser: WANG HONGFEI, BAI HEHE, XIE LEILEI, WANG WENMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of nitrosyl ruthenium complexes, and provides a nitrosyl ruthenium complex, a compound of the nitrosyl ruthenium complex and serum protein, preparation methods the nitrosyl ruthenium complex and the compound, and application of the compound. The chemical formula of the nitrosyl ruthenium complex is [RuCl3(5cqn)(NO)], wherein 5cqn is 5-chloro-8-hydroxyquinoline. The preparation method of the compound comprises the following steps: dissolving a complex crystal in water, adding the obtained solution into a human serum albumin (HSA) solution, conducting stirring, then performing reacting in a refrigerator with a temperature of 4 DEG C in a dark place for 2 days, and successively carrying out washing, filtering and concentrating to obtain a compound solution of the nitrosyl ruthenium complex and the serum protein; and mixing the compound solution of the nitrosyl ruthenium complex and the serum protein with a crystallization reagent solution, and conducting crystallizing