Carbamazepine sustained-release capsule preparation and preparation method thereof

The invention provides a carbamazepine sustained-release capsule preparation and a preparation method thereof, and relates to the technical field of medicines, in particular to the carbamazepine sustained-release capsule preparation and a method for enhancing the stability and increasing the yield o...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG HONGZHOU, GAO WEI, XU WENBIN, LI HAIJIAN, FAN JING, MAO XINFU, ZHAO ZHEN, XIE ZHILI, LI QINGXIA, HUANG YUANYANG, WU YAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a carbamazepine sustained-release capsule preparation and a preparation method thereof, and relates to the technical field of medicines, in particular to the carbamazepine sustained-release capsule preparation and a method for enhancing the stability and increasing the yield of the carbamazepine sustained-release capsule preparation. The carbamazepine sustained-release capsule disclosed by the invention is composed of a drug-loaded pellet core with a sustained-release effect and a gelatin hollow capsule. The composition of the sustained-release coating comprises a filling agent, an adhesive, a lubricant and a sustained-release coating material, and the composition of a coating layer comprises an amine alkyl methacrylate copolymer E100 and a quaternary amine methacrylate copolymer B type R100. The carbamazepine sustained-release capsule prepared by the invention is simple in prescription and high in bioavailability, and complexity and economic waste caused by excessive pharmaceutic adjuv